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タイトル別表記
肺腺癌においてdipeptidyl peptidase‑like 6 (DPP-6)遺伝子のDNAメチル化は予後の指標となる
ABERRANT METHYLATION OF DPP6 IN LUNG ADENOCARCINOMA
著者
ムンフジャラガル, バトヒシグ 徳島大学大学院保健科学研究科(保健学専攻)
Soejima, Shiho Tokushima University
Tegshee, Bilguun Case Western Reserve University
髙井, チカ子 Tokushima University
キーワード
lung cancer
DPP6
DNA
methylation
mRNA expression
prognosis
資料タイプ
学位論文
抄録
We previously performed the genome‑wide screening of aberrantly methylated CpG islands (CGIs) using the paired tumorous and non‑tumorous tissues of 12 lung adenocarcinomas (LADC). In comparisons with paired normal lung tissues, dipeptidyl peptidase‑like 6 (DPP6) has been identified as the most significantly hypermethylated CGI in LADC. DPP6 is a protein that modulates A‑type potassium channels in the somatodendritic compartments of neurons, which play a role in synaptic plasticity. Previous studies have showed that DPP6 is downregulated in cancers, such as acute myeloid leukemia and melanoma, but upregulated in colon cancer, which is attributed to hyper‑ and hypomethylation, respectively. The present study investigated the methylation and expression levels of DPP6 and its prognostic value in patients with LADC. The DNA methylation and mRNA expression levels of DPP6 in surgically resected LADC tissues were examined by bisulfite pyrosequencing and reverse transcription‑quantitative PCR, respectively. The DNA methylation and mRNA expression levels of DPP6 were both significantly higher in LADC tissues compared with in normal lung tissues (n=25; P<0.0001). Overall and disease‑free survival rates were significantly higher in LADC with high mRNA expression levels compared with those with low levels. In conclusion, epigenetic alterations in DPP6 were significantly higher in LADC tissues compared with in normal lung tissues, which may contribute to the malignant features and worse prognosis of these patients.
掲載誌名
Oncology Letters
ISSN
17921074
17921082
出版者
Spandidos Publications
25
5
開始ページ
206
発行日
2023-04-05
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Batkhishig Munkhjargalの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3805号
学位記番号
甲保第68号
学位授与年月日
2024-03-22
学位名
博士(保健学)
学位授与機関
徳島大学
部局
医学系
病院