ID | 119403 |
著者 |
Bando, Hiroki
Tokushima University
塚﨑, 佑貴
Tokushima University
Yabuki, Yohei
Tokushima University
米田, 浩人
Tokushima University
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キーワード | Lung adenocarcinoma
Oncomine dx target test
Comprehensive genomic profiling
FoundationOne CDx
Driver mutations
Epidermal growth factor receptor
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資料タイプ |
学術雑誌論文
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抄録 | A non-smoker woman with advanced lung adenocarcinoma was referred to us. The Oncomine Dx target test (ODxTT), a next-generation sequencing (NGS)-based hot spots panel test, did not detect any driver mutations, so we treated her with chemo-immunotherapy. After second-line chemotherapy, we performed FoundationOne CDx, a NGS-based comprehensive genomic profiling (CGP) test, and identified a rare variant of epidermal growth factor receptor exon 19 deletion that had not been covered by ODxTT. This case highlights the importance of considering the indication of a CGP test for patients who are likely to harbor driver mutations, even when ODxTT fails to detect any.
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掲載誌名 |
Respiratory Medicine Case Reports
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ISSN | 22130071
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出版者 | Elsevier
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巻 | 45
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開始ページ | 101893
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発行日 | 2023-07-07
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権利情報 | © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
理工学系
医学系
病院
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