直近一年間の累計
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ID 119403
著者
Bando, Hiroki Tokushima University
塚﨑, 佑貴 Tokushima University
Yabuki, Yohei Tokushima University
米田, 浩人 Tokushima University
キーワード
Lung adenocarcinoma
Oncomine dx target test
Comprehensive genomic profiling
FoundationOne CDx
Driver mutations
Epidermal growth factor receptor
資料タイプ
学術雑誌論文
抄録
A non-smoker woman with advanced lung adenocarcinoma was referred to us. The Oncomine Dx target test (ODxTT), a next-generation sequencing (NGS)-based hot spots panel test, did not detect any driver mutations, so we treated her with chemo-immunotherapy. After second-line chemotherapy, we performed FoundationOne CDx, a NGS-based comprehensive genomic profiling (CGP) test, and identified a rare variant of epidermal growth factor receptor exon 19 deletion that had not been covered by ODxTT. This case highlights the importance of considering the indication of a CGP test for patients who are likely to harbor driver mutations, even when ODxTT fails to detect any.
掲載誌名
Respiratory Medicine Case Reports
ISSN
22130071
出版者
Elsevier
45
開始ページ
101893
発行日
2023-07-07
権利情報
© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
理工学系
医学系
病院