ID | 119414 |
著者 |
Takeuchi, Eiji
National Hospital Organization Kochi Hospital
荻野, 広和
Tokushima University
Kondo, Kensuke
Tokushima University
Okano, Yoshio
National Hospital Organization Kochi Hospital
Ichihara, Seiya
National Hospital Organization Kochi Hospital
國重, 道大
National Hospital Organization Kochi Hospital
Kadota, Naoki
National Hospital Organization Kochi Hospital
Machida, Hisanori
National Hospital Organization Kochi Hospital
Hatakeyama, Nobuo
National Hospital Organization Kochi Hospital
Naruse, Keishi
National Hospital Organization Kochi Hospital
軒原, 浩
Tokushima University
|
キーワード | dynamic biomarker
immune checkpoint inhibitors
increased eosinophil count
non-small cell lung cancer
predictive factor
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資料タイプ |
学術雑誌論文
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抄録 | Background: An increased relative eosinophil count (REC) has potential as a predictive biomarker for a beneficial clinical response and outcome to cancer immunotherapies. Therefore, the present study investigated the impact of an increased posttreatment REC on the prognosis of non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs).
Methods: We retrospectively reviewed all 151 patients diagnosed with NSCLC and treated with ICI monotherapy and blood test data between March 2016 and August 2021 at National Hospital Organization Kochi Hospital and Tokushima University. Results: A total of 151 patients with a mean age of 69 years were included. REC after 4 weeks of initial ICI monotherapy was higher than pretreatment REC in 87 patients but not in 64. REC after 4 weeks of the ICI treatment with and without an increased REC were 4.4 and 1.8%, respectively (p < 0.001). Disease control rates (DCR) were significantly higher in patients with than in those without an increased REC (84% vs. 47%, p < 0.001). The median overall survival (OS) of lung cancer patients with or without an increased REC were 674 and 234 days, respectively. A Kaplan–Meier univariate analysis revealed a significant difference in OS between the two groups (p < 0.001). A Cox proportional regression analysis identified an increased REC as an independent predictor of OS (p = 0.003). Conclusion: ICI-treated NSCLC patients with an increased REC after 4 weeks of treatment had a better DCR and prognosis than the other patients examined. |
掲載誌名 |
Thoracic Cancer
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ISSN | 17597706
17597714
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出版者 | John Wiley & Sons Australia
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巻 | 15
|
号 | 3
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開始ページ | 248
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終了ページ | 257
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発行日 | 2023-12-12
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権利情報 | This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
病院
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