直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 119414
著者
Takeuchi, Eiji National Hospital Organization Kochi Hospital
荻野, 広和 Tokushima University
Kondo, Kensuke Tokushima University
Okano, Yoshio National Hospital Organization Kochi Hospital
Ichihara, Seiya National Hospital Organization Kochi Hospital
國重, 道大 National Hospital Organization Kochi Hospital
Kadota, Naoki National Hospital Organization Kochi Hospital
Machida, Hisanori National Hospital Organization Kochi Hospital
Hatakeyama, Nobuo National Hospital Organization Kochi Hospital
Naruse, Keishi National Hospital Organization Kochi Hospital
軒原, 浩 Tokushima University
キーワード
dynamic biomarker
immune checkpoint inhibitors
increased eosinophil count
non-small cell lung cancer
predictive factor
資料タイプ
学術雑誌論文
抄録
Background: An increased relative eosinophil count (REC) has potential as a predictive biomarker for a beneficial clinical response and outcome to cancer immunotherapies. Therefore, the present study investigated the impact of an increased posttreatment REC on the prognosis of non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs).
Methods: We retrospectively reviewed all 151 patients diagnosed with NSCLC and treated with ICI monotherapy and blood test data between March 2016 and August 2021 at National Hospital Organization Kochi Hospital and Tokushima University.
Results: A total of 151 patients with a mean age of 69 years were included. REC after 4 weeks of initial ICI monotherapy was higher than pretreatment REC in 87 patients but not in 64. REC after 4 weeks of the ICI treatment with and without an increased REC were 4.4 and 1.8%, respectively (p < 0.001). Disease control rates (DCR) were significantly higher in patients with than in those without an increased REC (84% vs. 47%, p < 0.001). The median overall survival (OS) of lung cancer patients with or without an increased REC were 674 and 234 days, respectively. A Kaplan–Meier univariate analysis revealed a significant difference in OS between the two groups (p < 0.001). A Cox proportional regression analysis identified an increased REC as an independent predictor of OS (p = 0.003).
Conclusion: ICI-treated NSCLC patients with an increased REC after 4 weeks of treatment had a better DCR and prognosis than the other patients examined.
掲載誌名
Thoracic Cancer
ISSN
17597706
17597714
出版者
John Wiley & Sons Australia
15
3
開始ページ
248
終了ページ
257
発行日
2023-12-12
権利情報
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院