ID | 119545 |
著者 |
Hakoi, Haruka
Tokushima University
Miki, Yoshimi
Tokushima University|The University of Tokyo
Nomura, Saki
Tokushima University
Nakajima, Kimiko
Kochi University
Terashima-Murase, Chiaki
Nagoya University
Takeichi, Takuya
Nagoya University
Sano, Shigetoshi
Kochi University
Akiyama, Masashi
Nagoya University
Sakasegawa, Shin-ichi
National Institute of Advanced Industrial Science and Technology|Asahi Kasei Pharma Corporation
Murakami, Makoto
The University of Tokyo|Japan Agency for Medical Research and Development
山本, 圭
Tokushima University|Japan Agency for Medical Research and Development
徳島大学 教育研究者総覧
KAKEN研究者をさがす
|
キーワード | Group IIF phospholipase A2
Lysoplasmalogen
Thermocrispum lysophospholipase D
Psoriasis
Lipidomics
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資料タイプ |
学術雑誌論文
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抄録 | Epidermal lipids play important roles in skin homeostasis and diseases. Psoriasis is an inflammatory disease characterized by keratinocyte hyperproliferation and Th17 immune responses. We previously reported that ethanolamine-type lysoplasmalogen (P-LPE), preferentially produced by group IIF secreted PLA2 (sPLA2-IIF/PLA2G2F) that is expressed in the suprabasal epidermis, promotes epidermal hyperplasia in psoriatic inflammation. Herein, we show that forcible degradation of epidermal P-LPE by topical application of recombinant lysophospholipase D (LyPls-PLD) from Thermocrispum, a lysoplasmalogen-specific hydrolase, attenuated epidermal hyperplasia and inflammation in imiquimod-induced and K5.Stat3C-transgenic mouse psoriasis models. In humans, P-LPE levels were elevated in the tape-stripped stratum corneum of patients with psoriasis. Moreover, in primary cultured human epidermal keratinocytes, aberrant cell proliferation and activation by psoriatic cytokines were sPLA2-IIF/P-LPE-dependent and were suppressed by the addition of LyPls-PLD with a decrease in P-LPE. These findings confirm that the sPLA2-IIF/P-LPE axis in the epidermis indeed regulates psoriasis, that P-LPE is a lipid biomarker that predicts the severity of psoriasis, and that pharmacological removal of this bioactive lipid is useful to prevent the disease. Thus, our study may lead to the development of drug discovery and diagnostic techniques based on this pathway.
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掲載誌名 |
Biochimie
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ISSN | 16386183
03009084
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cat書誌ID | AA11522535
AA00564792
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出版者 | Elsevier|Société Française de Biochimie et Biologie Moléculaire (SFBBM)
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巻 | 215
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開始ページ | 75
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終了ページ | 87
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発行日 | 2023-10-04
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権利情報 | © 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
著者版
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部局 |
生物資源系
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