Improvement of Asymmetric Reactions via Remote Electronic Tuning of N-Heterocyclic Carbene Catalysts

Aminoindanol-derived N-heterocyclic carbene catalysts have been widely used to achieve highly enantioselective reactions. Recently, substitution at the indane moiety of the catalysts has been found to have a great impact on the outcome of some reactions, even though the substituted position is distant from the carbene catalytic center. Especially, the introduction of an electron-withdrawing group improves the yield and enantioselectivity. This review provides an overview of recent reports on the improvement of N-heterocyclic-carbene-catalyzed asymmetric reactions by introducing electron-withdrawing remote substituents.

論文本文は2025-09-26以降公開予定
This is the peer reviewed version of the following article: Tsubasa Inokuma, Ken-ichi Yamada, ChemCatChem. 2024, 16, 22, e202401078., which has been published in final form at https://doi.org/10.1002/cctc.202401078. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.