アクセス数 : ?
ダウンロード数 : ?
ID 29055
著者
吉栖, 正典 Department of Pharmacology, The University of Tokushima School of Medicine
土屋, 浩一郎 Department of Pharmacology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
玉置, 俊晃 Department of Pharmacology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
reactive oxygen species
mitogen-activated protein kinase
signal transduction
cardiovascular disease
資料タイプ
学術雑誌論文
抄録
Reactive oxygen species (ROS), generated by reduction-oxidation (redox) reactions, have been recognized as important chemical mediators that regulate signal transduction. It has been reported that increase in ROS generation may relate to a risk for cardiovascular diseases such as atherosclerosis, angina pectoris, and myocardial infarction. Therefore, understanding the ROS-generating biological processes and ROS-induced intracellular signaling will be informative to gain insights into the pathogenesis of these diseases. In this review, we focus on the sources and reactions of ROS in the cardiovascular system and the role of mitogen-activated protein (MAP) kinase pathway in redox-mediated signal transduction. Clinical implications of ROS and MAP kinase are then described to provide insight into the pathogenesis of various redox-sensitive cardiovascular diseases. The pathways responsible for ROS generation in the cardiovascular system may provide novel therapeutic targets.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
48
1-2
開始ページ
11
終了ページ
24
並び順
11
発行日
2001
備考
EDB ID
フルテキストファイル
言語
eng
部局
薬学系
医学系