ID 53400
タイトルヨミ
ヤクブツ チリョウ ニツイテ
タイトル別表記
Pharmacological therapy in diabetes mellitus
著者
藤中, 雄一 徳島大学大学院ヘルスバイオサイエンス研究部生体制御医学講座生体情報内科学分野
キーワード
diabetes mellitus
pharmacological therapy
oral therapy
insulin therapy
資料タイプ
学術雑誌論文
抄録
Pharmacological therapy in diabetes mellitus has been changing in the last decade. Because conventional therapy for type 2 diabetes patients using sulfonylurea often caused secondary failure during long-term glycemic control, it was recognized that alpha-glucosidase inhibitors, metformin and thiazolidinedione which had hypoglycemic effects without exhaustion of beta cell function were beneficial. These drugs have efficacy not only for lowing plasma glucose concentration but for prevention of diabetes progression. Several clinical studies showed that angiotensin converting enzyme inhibitors, angiotensin Ⅱ receptor blockers and statins also had effects to prevent from type 2 diabetes. When we select diabetic therapy, especially to protect against the occurrence of macrovascular complications, it should be considered that type 2 diabetes has an aspect of metabolic syndrome. On the other hand, insulin therapy was reevaluated because of data from UKPDS and DCCT which demonstrated normoglycemia with intensive insulin therapy was critical goal to reduction in risk of diabetic complications. Very-rapid-acting insulin may be helpful for introduction of insulin therapy. To keep better glucose control, insulin may be considered until beta cell function is exhausted.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
62
5-6
開始ページ
187
終了ページ
190
並び順
187
発行日
2006-12-20
備考
EDB ID
164500
フルテキストファイル
言語
jpn