ID 65344
著者
ニシムラ, ユミコ Department of Dental Pathology and Medicine, Okayama University Dental School
小山, 保夫 Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
資料タイプ
紀要論文
抄録
In order to reveal some cytotoxic features of lidocaine, the effects of lidocaine at sublethal
concentrations (10 mM or less) on rat thymocytes were examined by the use of flow-cytometric
technique with fluorescent probes. Treatment with lidocaine at 3-10 mM for 1-3 hr
significantly increased intracellular Ca2+ and Zn2+ concentrations under normal condition.
After the removal of external Ca2+ and Zn2+, lidocaine still increased intracellular Ca2+ and Zn2+
concentrations, suggesting the lidocaine-induced release of intracellular Ca2+ and Zn2+.
Treatment with lidocaine at 0.3-1 mM for 24 hr significantly increased the populations of dead
cells and shrunken cells. Lidocaine at sublethal concentrations exerts some cellular actions
that are supposed to be linked to the cytotoxicity. The mechanism of lidocaine-induced cell
death varies in time- and concentration-dependent manners.
掲載誌名
徳島大学総合科学部自然科学研究 = Natural Science Research, The University of Tokushima
ISSN
09146385
cat書誌ID
AN10065859
出版者
徳島大学.総合科学部
24
1
開始ページ
1
終了ページ
5
並び順
1
発行日
2010-01-31
EDB ID
203984
フルテキストファイル
言語
eng
部局
生物資源系