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ID 76979
著者
遠藤, 陽介 Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
Han, Zhe-Hao Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
黒地, 潤 Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
坂田, 真宏 Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
前髙, 明典 Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
ヨネザワ, タカヤス Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
コイズミ, カズキ Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima
小山, 保夫 Division of Environmental Symbiosis Studies, Graduate School of Integrated Arts and Sciences, The University of Tokushima KAKEN研究者をさがす
キーワード
Zinc-pyrithione
Cytotoxicity
K562 cells
資料タイプ
紀要論文
抄録
Zinc-pyrithione is widely used as a topical agent. It may be likely that zinc-pyrithione possesses unique cytotoxic action because zinc exerts diverse actions on process of cell death. In this study, we examined the cytotoxicity of zinc-pyrithione on human leukemia K562 cells in order to examine the possibility of hormetic action. Zinc-pyrithione at concentrations ranging from 0.3 μM to 3 μM induced diverse actions on K562 cells. The agent at 0.3 and 1 μM significantly inhibited spontaneous occurrence of cell death during 72 h incubation while it was not the case for 3 μM. Significant decrease in population of shrunken cells was observed when the concentrations of zinc-pyrithione were 0.3 and 1 μM. Cell growth was significantly inhibited by 1 and 3 μM zinc-pyrithione, but not by 0.3 μM. Although the inhibition of cell growth by zinc-pyrithione was concentration-dependent, the inhibition of spontaneous cell death was observed only at lower concentrations (0.3 and 1 μM) of zinc-pyrithione. Results suggest that zinc-pyrithione possesses diverse actions, including hormetic action, on proliferative cells.
掲載誌名
徳島大学総合科学部自然科学研究 = Natural Science Research, The University of Tokushima
ISSN
09146385
cat書誌ID
AN10065859
25
3
開始ページ
15
終了ページ
19
並び順
15
発行日
2011
EDB ID
フルテキストファイル
言語
eng
部局
生物資源系