ID 77537
著者
アラナミ, フミト Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School
瀬川, 博子 Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
フルタニ, ジュンヤ Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School
クワハラ, ショウジ Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School
トミナガ, リエコ Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School
ハナブサ, エツヨ Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School
タツミ, サワコ Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School KAKEN研究者をさがす
キド, シンスケ Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School
イトウ, ミキコ School of Human Science and Environment, University of Hyogo
宮本, 賢一 Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
cadmium
FGF23
phosphate
transporter
proximal tubule
資料タイプ
学術雑誌論文
抄録
Phosphaturia has been documented following cadmium (Cd) exposure in both humans and experimental animals. The fibroblast growth factor 23 (FGF23)/klotho axis serves as an essential phosphate homeostasis pathway in the bone-kidney axis. In the present study, we investigated the effects of Cd on phosphate (Pi) homeostasis in mice. Following Cd injection into WT mice, plasma FGF23 concentration was significantly increased. Urinary Pi excretion levels were significantly higher in Cd-injected WT mice than in control group. Plasma Pi concentration decreased only slightly compared with control group. No change was observed in plasma parathyroid hormone and 1,25-dihydroxy vitamin D3 in both group of mice. We observed a decrease in phosphate transport activity and also decrease in expression of renal phosphate transporter SLC34A3 [NaPi-IIc/NPT2c], but not SLC34A1 [NaPi-IIa/NPT2a]. Furthermore, we examined the effect of Cd on Npt2c in Npt2a-knockout (KO) mice which expresses Npt2c as a major NaPi co-transporter. Injecting Cd to Npt2aKO mice induced significant increase in plasma FGF23 concentration and urinary Pi excretion levels. Furthermore, we observed a decrease in phosphate transport activity and renal Npt2c expression in Cd-injected Npt2a KO mice. The present study suggests that hypophosphatemia induced by Cd may be closely associated with the FGF23/klotho axis.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
1-2
開始ページ
95
終了ページ
108
並び順
95
発行日
2010-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
234198
フルテキストファイル
言語
eng
部局
医学系