ID 83817
著者
オオグシ, フミタカ Third Department of Internal Medicine, University Hospital, The University of Tokushima School of Medicine
谷, 憲治 Third Department of Internal Medicine, University Hospital, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
エンドウ, タケシ Third Department of Internal Medicine, University Hospital, The University of Tokushima School of Medicine
タダ, ヒロヤ Third Department of Internal Medicine, University Hospital, The University of Tokushima School of Medicine
カワノ, テツヤ Third Department of Internal Medicine, University Hospital, The University of Tokushima School of Medicine
アサノ, トオル Third Department of Internal Medicine, University Hospital, The University of Tokushima School of Medicine
Huang, Luping Third Department of Internal Medicine, University Hospital, The University of Tokushima School of Medicine
オオモト, ヤスカズ Cell Technology Institute, Otsuka Pharmaceutical Co., Ltd
ムラグチ, マサヒロ Cell Technology Institute, Otsuka Pharmaceutical Co., Ltd
森口, 博基 Division of Medical Informatics, University Hospital, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
曽根, 三郎 Third Department of Internal Medicine, University Hospital, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
autoantibodies
IL-1α
idiopathic pulmonary fibrosis
half life
radioimmunoassay
資料タイプ
学術雑誌論文
抄録
To clarify the clinical significance of autoantibodies to interleukin-1α (IL-1α autoantibodies) in rapidly progressive idiopathic pulmonary fibrosis ( IPF ), we measured the level of IL-1α autoantibodies in serum of 11 patients on the first hospital day, when patients were admitted due to severe symptoms, and on the 21st hospital day. IL-1α autoantibodies in serum were measured using radioimmunoassay, and the limitation of this assay for IL-1α autoantibodies was 5 ng/ml. These antibodies were detected in 5 of 11 patients on the first hospital day. On the 21st hospital day, these antibodies were detected in all patients, and its level was increased compared with that on the first hospital day. IL-1α autoantibodies that appeared in patients corresponded to that of IgG. The half life of exogeneous autoantibodies was investigated following administration of autoantibody rich plasma obtained from healthy blood donors to 6 control patients (CP) and 6 progressive IPF patients. These autoantibody levels in their serum were less than 5 ng/ml before administration. Serum was obtained at the indicated time after administration of IL-1α autoantibodies and the level of these autoantibodies in serum was measured, then the half life was calculated. Half life of exogeneous IL-1α autoantibodies in progressive IPF patients was significantly shorter than that in CP (71.3±31.8 hr vs 352.0±98.3 hr, p<0.01).These findings suggested that IL-1α autoantibodies were generated in response to the inflammatory process of rapidly progressive IPF and may act as a regulatory factor for IL-1α.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
48
3-4
開始ページ
181
終了ページ
189
並び順
181
発行日
2001
備考
EDB ID
136603
フルテキストファイル
言語
eng
部局
病院
医学系