ID 98230
タイトルヨミ
コウテンセイ QT エンチョウ ショウコウグン ノ ビョウタイ
タイトル別表記
The clinical state of acquired long QT syndrome
著者
山本, 浩史 徳島県立三好病院循環器科
キーワード
acquired long QT syndrome
torsade de pointes
magnesium
isoproterenol
reentry mechanism
資料タイプ
学術雑誌論文
抄録
The definition of long QT syndrome depends on demonstration of QT prolongation and recurrent syncope due to life-threatening ventricular arrhythmia . Acquired long QT syndromes are those due to drugs ( antiarrhythmic agents , antibiotics and phenothazines ), electrolyte abnormalities , acute ischemia and heart block. The ventricular arrhythmia is of a unique type known as torsade de pointes (TdP), which is characterized by rapid rates and gradually changing QRS morphology. Recently, It is reported that the cause of congenital long QT syndrome was abnormalities of gene coded myocardial ion channel, and some of acquired long QT syndrome was associated with congenital abnormalities of ion channel gene. In treatment of acquired long QT syndrome, the first step is to stop administration of the causative drug if can be identified. The aim of the therapy of TdP is to shorten and unify the uneven ventricular repolarization ; that is to correct the underlying electrophysiological disorder . Ventricular pacing and isoproterenol frequently prevent recurrent episodes of TdP by shortening action potential duration. Magnesuim is useful in treating TdP. The antiarrhythmic effect of magnesuim is due to shortening of the duration of ventricular vulnerable period during the cardiac cycle and prevention of ventricular arrhythmias related to reentry mechanism.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
61
5-6
開始ページ
135
終了ページ
139
並び順
135
発行日
2005-12-20
備考
フルテキストファイル
言語
jpn