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ID 117800
タイトル別表記
CHARACTER OF QAC RESISTANT P. AERUCINOSA
著者
前田, 拓也 The University of Tokushima
キーワード
Quaternary ammonium compound
Pseudomonas aeruginosa
Disinfectant resistance
Cell surface hydrophobicity
Biofilm
資料タイプ
学術雑誌論文
抄録
We developed the resistance of Pseudomonas aeruginosa ATCC 10145 to N-dodecylpyridinium iodide (P-12), a quaternary ammonium compound (QAC), by using a standard broth dilution method and compared its characteristics with those of the sensitive strain. The minimum inhibitory concentration (MIC) against the resistant strain was 8 times higher than that against the sensitive strain and the adapted resistance to P-12 was stable. Population analysis showed that there were some variations in the extent of the resistance of P. aeruginosa to P-12. The cell surface of the resistant strain was more hydrophilic than that of the sensitive strain. In order to investigate the relationship between the resistance to P-12 and the biofilm formation of P. aeruginosa, alginic acid was isolated and its concentration was determined. The results revealed that the alginic acid was produced only in the resistant strain. Moreover, the observation by scanning electron microscope (SEM) of both strains showed that many clusters of bacteria were seen only in the resistant strain. These results suggested that not only the hydrophilic change of cell surface but also the biofilm formation is involved in the resistance of P. aeruginosa to P-12.
掲載誌名
Biocontrol Science
ISSN
13424815
18840205
cat書誌ID
AA11169621
出版者
The Society for Antibacterial and Antifungal Agents, Japan
7
3
開始ページ
147
終了ページ
153
発行日
2002-11-20
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系