ID | 117800 |
タイトル別表記 | CHARACTER OF QAC RESISTANT P. AERUCINOSA
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著者 |
前田, 拓也
The University of Tokushima
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キーワード | Quaternary ammonium compound
Pseudomonas aeruginosa
Disinfectant resistance
Cell surface hydrophobicity
Biofilm
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資料タイプ |
学術雑誌論文
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抄録 | We developed the resistance of Pseudomonas aeruginosa ATCC 10145 to N-dodecylpyridinium iodide (P-12), a quaternary ammonium compound (QAC), by using a standard broth dilution method and compared its characteristics with those of the sensitive strain. The minimum inhibitory concentration (MIC) against the resistant strain was 8 times higher than that against the sensitive strain and the adapted resistance to P-12 was stable. Population analysis showed that there were some variations in the extent of the resistance of P. aeruginosa to P-12. The cell surface of the resistant strain was more hydrophilic than that of the sensitive strain. In order to investigate the relationship between the resistance to P-12 and the biofilm formation of P. aeruginosa, alginic acid was isolated and its concentration was determined. The results revealed that the alginic acid was produced only in the resistant strain. Moreover, the observation by scanning electron microscope (SEM) of both strains showed that many clusters of bacteria were seen only in the resistant strain. These results suggested that not only the hydrophilic change of cell surface but also the biofilm formation is involved in the resistance of P. aeruginosa to P-12.
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掲載誌名 |
Biocontrol Science
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ISSN | 13424815
18840205
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cat書誌ID | AA11169621
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出版者 | The Society for Antibacterial and Antifungal Agents, Japan
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巻 | 7
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号 | 3
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開始ページ | 147
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終了ページ | 153
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発行日 | 2002-11-20
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
生物資源系
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