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ID 109502
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新規アポトーシス関連タンパク質ヌクリングはNF-κBとSTAT3の調節を介して乳腺退縮を制御する
Nucling Regulates Mammary Gland Involution
著者
ヴァン ダン, フィー 徳島大学大学院医科学教育部(医学専攻)
坂井, 隆志 Tokushima University|Tokushima Bunri University KAKEN研究者をさがす
Anh Pham, Tuan Tokushima University|Vietnam National University
Hong Tran, Diem Tokushima University|Vietnam National University
キーワード
apoptosis
macrophage
NF-κB
STAT3
nucling
mammary gland involution
資料タイプ
学位論文
抄録
Postpartum mammary gland involution is the physiological process by which the lactating gland returns to its pre-pregnant state. In rodent models, the microenvironment of mammary gland involution is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. Therefore, a deeper understanding of the physiological regulation of involution may provide in-depth information on breast cancer therapy. We herein identified Nucling as an important regulator of involution of the mammary gland. A knock-out mouse model was generated and revealed that postpartum involution were impaired in mice lacking Nucling. Involution is normally associated with an increase in the activation of NF-κB and STAT3, which is required for the organized regulation of involution, and was observed in WT glands, but not in the absence of Nucling. Furthermore, the loss of Nucling led to the suppression of Calpain- 1, IL-6, and C/EBPδ factors, which are known to be essential for normal involution. The number of M2 macrophages, which are crucial for epithelial cell death and adipocyte repopulation after weaning, was also reduced in Nucling-KO glands. Taken together, the results of the present study demonstrated that Nucling played an important role in mammary gland involution by regulating NF-κB and STAT3 signaling pathways.
掲載誌名
Journal of Biological Chemistry
ISSN
1083351X
cat書誌ID
AA1202441X
出版者
American Society for Biochemistry and Molecular Biology
290
40
開始ページ
24626
終了ページ
24635
発行日
2015-08-11
備考
内容要旨・審査要旨・論文全文の公開:
内容要旨・審査要旨 : LID201510261009.pdf
論文全文 : k2883_fulltext.pdf
著者の申請により要約(2015-10-26公開)に替えて論文全文を公開(2018-12-05)
本論文は, 著者Huy Van Dangの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© the American Society for Biochemistry and Molecular Biology.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2883号
学位記番号
甲医第1260号
学位授与年月日
2015-09-24
学位名
博士(医学)
学位授与機関
徳島大学
部局
先端酵素学研究所