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ダウンロード数 : ?
ID 111587
著者
Sakakibara, Hiroyuki The University of Tokushima
Ishida, Kaori The University of Tokushima
井澤, 有紀 The University of Tokushima
Minami, Yuko The University of Tokushima
Saito, Satomi The University of Tokushima
河合, 慶親 The University of Tokushima KAKEN研究者をさがす
Butterweck, Veronika University of Florida
キーワード
depression
forced swimming test
brain function
serotonergic ratio
ERK1/2
資料タイプ
学術雑誌論文
抄録
Chronic stress has been reported to be an essential factor for depression. In this study, the effect of forced swimming stress on neurotransmitters and cellular signaling pathway contributing to brain functions was investigated using the forced swimming test (FST) in order to understanding of mechanisms to regulate stress signals in brain. Antidepressant drug, imipramine, significantly reduced the immobility time of male rats in the FST by 85% at a dose of 15mg/kg for 2 weeks. This result indicated that the swimming stress caused a depressed state in the rats without administration of imipramine. Swimming stress significantly lowered the serotonergic ratio and also markedly enhanced the phosphorylation of ERK1/2 in the hypothalamus region compared to the rats without FST. These phenomena maybe included in key mechanisms of the development of depression.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
52
Supplement
開始ページ
300
終了ページ
301
並び順
300
発行日
2005-11
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系