アクセス数 : ?
ダウンロード数 : ?
ID 114632
タイトル別表記
Hereditary breast cancer
遺伝性乳癌卵巣癌症候群
著者
竹原, 恵美 徳島大学
笹, 聡一郎 徳島大学
キーワード
HBOC
BRCA
RRSO
CRRM
資料タイプ
学術雑誌論文
抄録
Hereditary breast and ovarian cancer(HBOC)syndrome is an autosomal dominant genetic disease, which represents about 5% of all breast cancers. The pathogenic mutations in the BRCA 1/2genes involved in DNA repair pathway are known to be associated with an increased risk of not only breast cancer and ovarian cancer but also prostate cancer, pancreatic cancer and male breast cancer. The risk reduction management is required for BRCA mutation-positive patients. The surveillance using breast magnetic resonance imaging(MRI)is recommended for early detection of breast cancer in HBOC patients. Furthermore, it has been reported that risk reducing salpingooophorectomy(RRSO)reduces mortality caused by breast cancer and ovarian cancer, and contralateral risk-reducing mastectomy(CRRM)improves the overall survival in postoperative breast cancer patients.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
75
5-6
開始ページ
149
終了ページ
154
並び順
149
発行日
2019-12-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系
病院