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ダウンロード数 : ?
ID 113448
タイトル別表記
PTH-related protein and cancer
著者
Nakamura, Yuriko The University of Tokushima
板東, 浩 The University of Tokushima KAKEN研究者をさがす
Shintani, Yasumi The University of Tokushima
Yokogoshi, Yutaka The University of Tokushima
Saito, Shiro The University of Tokushima
資料タイプ
学術雑誌論文
抄録
The clinical significance of parathyroid hormone-related protein in humoral hypercalcemia of malignancy was investigated by determining the serum parathyroid hormone-related protein concentrations in 167 normal subjects, 56 patients with hematologic malignancy and 144 patients with solid tumor. Serum parathyroid hormone-related protein was measured with a radioimmunoassay kit that recognizes the C-terminal portion of the molecule. The serum parathyroid hormone-related protein concentrations were 20.2–50.8 pmol/l (mean±2 SD) in normal subjects, and were elevated in 80% of the patients with malignancies with hypercalcemia, including squamous cell carcinoma and adult T cell leukemia. Moreover, two cases of B cell non-Hodgkin's lymphoma with hypercalcemia had high serum parathyroid hormone-related protein concentrations, which varied in parallel with the tumor size during the clinical course. Of 136 patients with solid tumors with normocalcemia, the serum parathyroid hormone-related protein concentration was slightly elevated in only 5.1%, all of whom were at an advanced stage. These data indicate that determination of the serum parathyroid hormone-related protein concentration is useful for differential diagnosis of humoral hypercalcemia of malignancy and prediction of its development.
掲載誌名
Acta Endocrinologica
ISSN
00015598
cat書誌ID
AA00507325
127
4
開始ページ
324
終了ページ
330
発行日
1992-10
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系