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ID 113698
著者
Ebe, K Takao Hospital|Japan Low Carbohydrate Diet Promotion Association
板東, 浩 Japan Low Carbohydrate Diet Promotion Association|Tokushima University KAKEN研究者をさがす
Muneta, T Japan Low Carbohydrate Diet Promotion Association|Muneta Maternity Clinic
Bando, M Tokushima University
Yonei, Y Doshisha University
キーワード
area under the curves (AUC)
insulinogenic index (IGI)
type 2 diabetes mellitus (T2DM)
morbus value (M value)
delta ratio of IGI
AUC ratio of IGI
資料タイプ
学術雑誌論文
抄録
Background: Type 2 diabetes mellitus (T2DM) has been a medical and social problem worldwide. For nutritional therapy, Low Carbohydrate Diet (LCD) and Calorie restriction (CR) have discussed for long, where authors continued clinical research.
Subjects and Methods: Subjects were 68 patients with T2DM with 62.1 years on average. Methods included i) standard CR was provided a day with 1400 kcal and 60% of carbohydrate, ii) measurement of daily profile of blood glucose, iii) insulinogenic index (IGI) (0-30 mins) exam for breakfast including 70g of carbohydrate, iv) calculation of IGI by delta and Area Under the Curves(AUC).
Results: Basal data revealed that HbA1c 7.9%, fasting glucose 163 mg/dL, average glucose in a day 210 mg/dL, M value 117 in the median. Increment of glucose/IRI was 48.0 mg/dL/8.6 μU/mL, respectively. Delta or AUC ratio of IGI was 0.14[0.08-0.26] and 3.3[2.5-5.2], respectively. There were significant correlations between M value and Delta or AUC ratio, with a higher coefficient in the latter.
Discussion and Conclusion: IGI study in Meal Tolerance Test (MTT) would be useful for pancreas function evaluation. AUC ratio method has superiority than Delta ratio with higher correlation coefficient. Current results could be the fundamental data for the related range of research, and further development will be expected.
掲載誌名
Series of Endocrinology, Diabetes and Metabolism
出版者
SeriesScience International
1
1
開始ページ
3
終了ページ
15
発行日
2019-02-01
権利情報
Copyright © 2019 Ebe K et al. This is an open access article and is distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系