| ID | 118983 |
| 著者 |
板東, 浩
Tokushima University|Medical Research|Japan Low Carbohydrate Diet Promotion Association
KAKEN研究者をさがす
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| キーワード | Action to Control Cardiovascular Risk in Diabetes (ACCORD)
major adverse cardiovascular events (MACE)
heterogeneous treatment effects (HTE)
genome-wide association study (GWAS)
modified dynamic time-warping approach (etwDTW)
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| 資料タイプ |
学術雑誌論文
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| 抄録 | Action to Control Cardiovascular Risk in Diabetes (ACCORD) has been diabetic mega study and analyzed cardiovascular disease (CVD) and major adverse cardiovascular events (MACE). Recently, subgroup analyses have showed heterogeneous treatment effects (HTE). Using genome-wide association study (GWAS) and modified dynamic time-warping approach (etwDTW), presence of subgroups (C1-4) was suggested. Four-month strict treatment resulted in HbA1c 6.7%, 7.0%, 7.7% and 6.2%, respectively. The hazard ratio (HR) for C4/C3 showed: MACE 0.27/1.60, total mortality 0.33/2.52, hypoglycemia 0.33/1.66, and microvascular outcome 0.86/1.30. C4 showed suggestive significance of single-nucleotide polymorphism (SNP) for rs220732, in MAS1. Future diabetology may proceed to individualization medicine.
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| 掲載誌名 |
International Journal of Endocrinology and Diabetes
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| ISSN | 26943875
|
| 出版者 | Pubtexto Publishers
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| 巻 | 5
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| 号 | 3
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| 開始ページ | 139
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| 発行日 | 2022-06-30
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| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
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| 著者版フラグ |
出版社版
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| 部局 |
医学系
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