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ID 112130
タイトル別表記
Current status of hematopoietic stem cell transplantation and umbilical cord blood bank in Chugoku-Shikoku area
著者
河野, 嘉文 徳島大学
金丸, 幸代 徳島大学
渡辺, 力 徳島大学
大西, 敏弘 徳島大学
廣瀬, 政雄 徳島大学
島, 健二 徳島大学
中山, 孝善 中山産婦人科
キーワード
cord blood cell transplantation
hematopoietic stem cell
graft versus host disease
cord blood bank
HLA
資料タイプ
学術雑誌論文
抄録
The hematopoietic stem cell transplantation (HSCT) is rapidly and widely spreading in the treatment strategy of various types of cancers, since peripheral and umbilical cord blood (CB) have been introduced as new sources of transplantable cells in addition to ordinary bone marrow cells. In this report, the current status of HSCT was reviewed. CB is rich in hematopoietic stem/progenitor cells, which have high proliferative potential. T cells in CB are speculated to be immature and immune-tolerable cells with less potential to cause acute or chronic graft versus host disease (GVHD), which are directly related with transplant-related morbidity and mortality. Furthermore, transplants with CB are not strictly restricted by a HLA-disparity. On the other hand, the less number of collected cells from CB is a major problem when the cells are applied for clinical transplantation, because the lower number of infused cells often result in engraftment failure. Further, we have no data of the viability after long term cryopreservation. We must carefully judge the usefulness of CB as a cell source for transplantation, but the benefits of CB may have a possibility to overcome these disadvantage in the near future. Finally, the activity of cord blood bank in Chugoku-Shikoku area, which was started from August 1998, was also introduced.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
55
2
開始ページ
49
終了ページ
54
並び順
49
発行日
1999-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
病院
医学系