山下, 祥子 Tokushima University KAKEN研究者をさがす
森根, 裕二 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
居村, 暁 Tokushima University KAKEN研究者をさがす
池本, 哲也 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
齋藤, 裕 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
髙須, 千絵 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
山田, 眞一郎 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
徳田, 和憲 Tokushima University
沖川, 昌平 Tokushima University
宮崎, 克己 Tokushima University
尾矢, 剛志 Tokushima University 徳島大学 教育研究者総覧
常山, 幸一 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
島田, 光生 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Background: No universal classification method for intrahepatic cholangiocarcinoma (IHCC) has been reported based on the embryological origin of biliary epithelial cells. The aim of this study was to classify IHCC according to protein expression levels of somatostatin receptor 2 (SSTR2) and b-cell leukemia/lymphoma 2 (Bcl2) and to elucidate the clinicopathological features of each group.
Methods: Fifty-two IHCC patients who underwent hepatic resection were enrolled in this study. Protein expression levels of SSTR2 and Bcl2 were examined using immunohistochemistry. Clinicopathological factors were compared between the three groups and prognostic factors were investigated.
Results: The patients were divided into three groups: SSTR2 positive and Bcl2 negative (p-Group H, n = 21), SSTR2 negative and Bcl2 positive (p-Group P, n = 14), and the indeterminate group (p-Group U, n = 17) for cases where SSTR2 and Bcl2 were both positive or both negative. All p-Group P cases displayed curability A or B. The 5-year survival rates of p-Group H and U patients were worse than those in p-Group P. p-Group H had higher T-factor, clinical stage, and incidence of periductal infiltration than p-Group P.
Conclusions: This method could be used to classify IHCC into peripheral and perihilar type by embryological expression patterns of SSTR2 and Bcl2.
World Journal of Surgical Oncology
BioMed Central|Springer Nature
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