直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 116613
著者
Kitagawa, Akihiro Kyushu University
Kobayashi, Yuta Kyushu University
Takao, Seiichiro Kyushu University
Kosai, Keisuke Kyushu University
Mimori, Koshi Kyushu University
Tanaka, Yasuhito Kumamoto University
キーワード
genome-wide analysis
methylation
tumor suppressor gene
prognostic biomarker
hepatocellular carcinoma
資料タイプ
学術雑誌論文
抄録
Genome-wide analysis is widely applied to detect molecular alterations during oncogenesis and tumor progression. We analyzed DNA methylation profiles of hepatocellular carcinoma (HCC), and investigated the clinical role of most heypermethylated of tumor, encodes T-box 15 (TBX15), which was originally involved in mesodermal differentiation. We conducted a genome-wide analysis of DNA methylation of tumor and non-tumor tissue of 15 patients with HCC, and revealed TBX15 was the most hypermethylated gene of tumor (Beta-value in tumor tissue = 0.52 compared with non-tumor tissue). Another validation set, which comprised 58 HCC with radical resection, was analyzed to investigate the relationships between tumor phenotype and TBX15 mRNA expression. TBX15 mRNA levels in tumor tissues were significantly lower compared with those of nontumor tissues (p < 0.0001). When we assigned a cutoff value = 0.5-fold, the overall survival 5-year survival rates of the low-expression group (n = 17) were significantly shorter compared with those of the high-expression group (n = 41) (43.3% vs. 86.2%, p = 0.001). Multivariate analysis identified low TBX15 expression as an independent prognostic factor for overall and disease-free survival. Therefore, genome-wide DNA methylation profiling indicates that hypermethylation and reduced expression of TBX15 in tumor tissue represents a potential biomarker for predicting poor survival of patients with HCC.
掲載誌名
Oncotarget
ISSN
19492553
出版者
Impact Journals
11
52
開始ページ
4803
終了ページ
4812
発行日
2020-12-29
権利情報
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0) (https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院