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ID 113350
タイトル別表記
高血圧性心疾患における左室拡張期電気機械的カップリングの非侵襲的評価法
Electromechanical Coupling in HHD
著者
齋藤, 友子 徳島大学大学院医科学教育部(医学専攻)
キーワード
Tpeak-Tend interval
E/e'
hypertension
diastolic electromechanical coupling
資料タイプ
学位論文
抄録
Background: There is a need to stratify patients who may develop heart failure because of the current “heart failure pandemic”. We hypothesized that noninvasive assessment of diastolic electromechanical coupling by electrocardiography and Doppler echocardiography may be clinically useful for risk stratification of hypertensive patients who may develop heart failure.
Methods: We measured the time from the peak to end of the T-wave (TpTe) as an electrophysiological parameter, and peak early-diastolic mitral flow (E) and lateral annular (e’) velocities as mechanical parameters in 109 patients with hypertension. Relationships between these parameters and their association with the prognosis was evaluated.
Results: The e’ was inversely correlated with TpTe (p<0.001) and QTc (p < 0.014), whereas E/e’ was positively correlated with TpTe (p<0.001) and QTc (p<0.001). The TpTe predicted patients with E/e’ > 12. There were 24 cardiovascular events during follow-up (57 ± 20 months), and Kaplan-Meir analysis showed that outcome was worse (p=0.003) in patients with higher E/e’ than lower E/e’, however, there was no difference between patients with longer TpTe (≧72 msec) and shorter TpTe (<72 msec).
Conclusions: The correlation of TpTe with e’ and E/e’ in hypertensive patients suggests that these parameters reflect diastolic ventricular electromechanical coupling. The E/e’ predicted outcome, and an elevated E/e’ should be suspected when TpTe is prolonged (> 72 msec). Noninvasive evaluation of diastolic electromechanical coupling is clinically useful in patients with hypertension.
掲載誌名
Journal of Echocardiography
ISSN
13490222
1880344X
cat書誌ID
AA12042477
AA12047288
出版者
Japanese Society of Echocardiography|Springer nature
17
4
開始ページ
206
終了ページ
212
発行日
2019-02-12
備考
内容要旨・審査要旨・論文要約の公開
本文全文は後日公開予定。
The final publication is available at link.springer.com: https://doi.org/10.1007/s12574-019-00421-4
本論文は, 著者Yuko Saitoの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
jpn
著者版フラグ
その他
文科省報告番号
甲第3266号
学位記番号
甲医第1415号
学位授与年月日
2019-03-19
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系