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ID 116479
タイトル別表記
Varying clinical presentations of NTM disease
著者
篠原, 勉 Tokushima University|Japan Agricultural Cooperatives Kochi Hospital|National Hospital Organization Kochi Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
森住, 俊 Tokushima University|Japan Agricultural Cooperatives Kochi Hospital 徳島大学 教育研究者総覧
Sumitomo, Kenya Japan Agricultural Cooperatives Kochi Hospital
キーワード
nontuberculous mycobacteria
tuberculosis
acid-fast bacteria tests
extrapulmonary diseases
immune reconstitution inflammatory syndrome
資料タイプ
学術雑誌論文
抄録
The incidence rate of pulmonary nontuberculous mycobacterial disease (PNTMD) in Japan is the highest among major industrialized nations. Although the typical clinical course and radiological manifestations of PNTMD are different from those of pulmonary tuberculosis (TB), confusion about these mycobacterial diseases leads to a diagnostic pitfall. Diagnostic challenges include the coexistence of Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM), false positives for NTM in MTB nucleic acid amplification tests, microbial substitution, and abnormal radiological manifestations caused by NTM. Features of extrapulmonary NTM diseases, such as pleurisy, vertebral osteomyelitis, and disseminated disease, are different from the corresponding tuberculous diseases. Moreover, the immunological background of the patient (status of human immunodeficiency virus infection with or without antiviral therapy, continuation or discontinuation of immunosuppressive therapy, use of immune checkpoint inhibitor, pregnancy and delivery, etc.) influences the pathophysiology of mycobacterial diseases. This review describes the varying clinical presentations of NTM disease with emphasis on the differences from TB.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
68
3-4
開始ページ
220
終了ページ
227
並び順
220
発行日
2021-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系