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ID 113941
著者
Nishikiori, Nanako Tokushima University
Nakamura, Akihito Tokushima University
Miyagi, Murasaki Tokushima University
Shibata, Nao Tokushima University
キーワード
o-phthalaldehyde
isoindole
steric protection
isoindolin-1-one
資料タイプ
学術雑誌論文
抄録
o-Phthalaldehyde (OPA) reacts with O-protected tris(hydroxyalkyl) aminomethanes in the presence of 1-propanethiol to afford a novel class of stable isoindoles. Steric protection provided by the bulkiness of C3-symmetric primary amines derived from tris(hydroxymethyl)aminomethane could be significant for the stabilization of 1-alkylthio-2-alkyl-substituted isoindoles derived from OPA. A plausible reaction mechanism is proposed to explain the formation of the isoindole and an isoindolin-1-one by-product.
掲載誌名
SynOpen
ISSN
25099396
出版者
Georg Thieme Verlag Stuttgart
2
1
開始ページ
50
終了ページ
57
発行日
2018-02-20
権利情報
This article is published under the Creative Commons license CC BY-NC-ND (Attribution-NonCommercial-NoDerivatives)(https://creativecommons.org/licenses/by-nc-nd/4.0/)
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出版社版DOI
出版社版URL
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言語
eng
著者版フラグ
出版社版
部局
薬学系
技術支援部
歯学系