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T1-CUBE法と3D-SPGR法による脳腫瘍造影増強効果の比較
Brain Tumor CE on T1-Cube versus 3D SPGR
著者
ムングンホーヤグ, マジグスレン 徳島大学大学院医科学教育部(医学専攻)
影治, 照喜 The University of Tokushima KAKEN研究者をさがす
松崎, 健司 The University of Tokushima KAKEN研究者をさがす
キーワード
三次元 fast spoiled gradient recall acquisition in steady state (3D FSPGR)
脳腫瘍
造影磁気共鳴画像
T1-Cube シーケンス
brain tumor
contrast-enhanced magnetic resonance imaging (CE MRI)
T1-Cube sequence
3-dimensional fast spoiled gradient recall acquisition in steady state (3D FSPGR)
資料タイプ
学位論文
抄録
Purpose: T1-Cube (GE HealthCare) is a relatively new 3-dimensional (3D) fast spin-echo (FSE)-based magnetic resonance (MR) imaging sequence that uses a variable flip angle to acquire gap-free volume scans. We compared the gadolinium enhancement characteristics of a heterogeneous population of brain tumors imaged by T1-Cube and then 3D fast spoiled gradient recall acquisition in steady state (3D FSPGR) 3-tesla MR imaging to identify the superior modality for specific diagnostic purposes.
Methods: We examined 61 lesions from 32 patients using the 2 sequences after administration of gadopentetic acid (Gd-DTPA; 0.1 mmol/kg). Two neuroradiologists independently measured each lesion twice using a region-of-interest (ROI) method. We measured the contrast-to-noise ratio (CNR), the difference in signal intensity (SI) between the tumor and normal white matter relative to the standard deviation (SD) of the SI within the lesion, for both post-contrast 3D FSPGR and post-contrast T1-Cube images of the same tumor and compared modality-specific CNRs for all tumors and in subgroups defined by tumor size, enhancement ratio, and histopathology.
Results: The mean CNR was significantly higher on T1-Cube images than 3D FSPGR images for the total tumor population (1.85 ± 0.97 versus 1.12 ± 1.05, P < 0.01) and the histologic types, i.e., metastasis (P < 0.01) and lymphoma (P < 0.05). The difference in CNR was even larger for smaller tumors in the metastatic group (4.95 to 23.5 mm2) (P < 0.01). In contrast, mean CNRs did not differ between modalities for high grade glioma and meningioma.
Conclusions: Gadolinium enhancement of brain tumors was generally higher when imaged by T1-Cube than 3D FSPGR, and T1-Cube with Gd enhancement may be superior to 3D FSPGR for detecting smaller metastatic tumors.
掲載誌名
Magnetic Resonance in Medical Sciences
ISSN
18802206
13473182
cat書誌ID
AA12036292
AA11648770
出版者
Japanese Society for Magnetic Resonance in Medicine
15
1
開始ページ
34
終了ページ
40
発行日
2016-01-01
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201506251002.pdf
論文本文 : LID201601251001.pdf
本論文は, 著者Mungunkhuyag Majigsurenの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2855号
学位記番号
甲医第1251号
学位授与年月日
2015-05-28
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院