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ID 114461
タイトル別表記
Drug Repositioning for Cardiac Arrest
著者
Niimura, Takahiro Tokushima University
Koyama, Toshihiro Okayama University
Shigemi, Yuta Okayama University
Morita, Mizuki Okayama University
Ohshima, Ayako Okayama University
Harada, Keisaku Kitakyushu City Yahata Hospital
Imai, Toru Nihon University
Hagiwara, Hiromi Nagoya City University
中馬, 真幸 Tokushima University
Kondo, Yutaka Juntendo University
Hinotsu, Shiro Sapporo Medical University
Kano, Mitsunobu R. Okayama University
キーワード
cardiac arrest
drug repositioning
claims database
drug discovery tool
vasodilator
資料タイプ
学術雑誌論文
抄録
The survival rate of cardiac arrest patients is less than 10%; therefore, development of a therapeutic strategy that improves their prognosis is necessary. Herein, we searched data collected from medical facilities throughout Japan for drugs that improve the survival rate of cardiac arrest patients. Candidate drugs, which could improve the prognosis of cardiac arrest patients, were extracted using “TargetMine,” a drug discovery tool. We investigated whether the candidate drugs were among the drugs administered within 1 month after cardiac arrest in data of cardiac arrest cases obtained from the Japan Medical Data Center. Logistic regression analysis was performed, with the explanatory variables being the presence or absence of the administration of those candidate drugs that were administered to ≥10 patients and the objective variable being the “survival discharge.” Adjusted odds ratios for survival discharge were calculated using propensity scores for drugs that significantly improved the proportion of survival discharge; the influence of covariates, such as patient background, medical history, and treatment factors, was excluded by the inverse probability-of-treatment weighted method. Using the search strategy, we extracted 165 drugs with vasodilator activity as candidate drugs. Drugs not approved in Japan, oral medicines, and external medicines were excluded. Then, we investigated whether the candidate drugs were administered to the 2,227 cardiac arrest patients included in this study. The results of the logistic regression analysis showed that three (isosorbide dinitrate, nitroglycerin, and nicardipine) of seven drugs that were administered to ≥10 patients showed significant association with improvement in the proportion of survival discharge. Further analyses using propensity scores revealed that the adjusted odds ratios for survival discharge for patients administered isosorbide dinitrate, nitroglycerin, and nicardipine were 3.35, 5.44, and 4.58, respectively. Thus, it can be suggested that isosorbide dinitrate, nitroglycerin, and nicardipine could be novel therapeutic agents for improving the prognosis of cardiac arrest patients.
掲載誌名
Frontiers in Pharmacology
ISSN
16639812
出版者
Frontiers Media S.A.
10
開始ページ
1257
発行日
2019-11-08
権利情報
Copyright © 2019 Zamami, Niimura, Koyama, Shigemi, Izawa-Ishizawa, Morita, Ohshima, Harada, Imai, Hagiwara, Okada, Goda, Takechi, Chuma, Kondo, Tsuchiya, Hinotsu, Kano and Ishizawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). (https://creativecommons.org/licenses/by/4.0/) The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
薬学系
病院