直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 116895
タイトル別表記
Drug-Repositioning Approaches Based on Database
著者
座間味, 義人 Tokushima University|Okayama University KAKEN研究者をさがす
キーワード
drug repositioning
database
medical information database
life science databases
existing drugs
資料タイプ
学術雑誌論文
抄録
Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost and time required for drug development is reduced. Conventional drug repositioning has been dominated by a method involving the search for candidate drugs that act on the target molecules of an organism in a diseased state through basic research. However, recently, information hosted on medical information and life science databases have been used in translational research to bridge the gap between basic research in drug repositioning and clinical application. Here, we review an example of drug repositioning wherein candidate drugs were found and their mechanisms of action against a novel therapeutic target were identified via a basic research method that combines the findings retrieved from various medical and life science databases.
掲載誌名
Frontiers in Pharmacology
ISSN
16639812
出版者
Frontiers Media S.A.
12
開始ページ
752174
発行日
2021-11-01
権利情報
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院