ID 83833
著者
Batmunkh, Rentsenkhand Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School
西岡, 安彦 Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
青野, 純典 Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School KAKEN研究者をさがす
東, 桃代 Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キノシタ, カツヒロ Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School KAKEN研究者をさがす
岸, 潤 Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School KAKEN研究者をさがす
マキノ, ヒデキ Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School
キシ, マサミ Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School
タケザキ, アキオ Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School
曽根, 三郎 Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
CCN
integrin
proliferation
fibroblasts
focal adhesion kinas
資料タイプ
学術雑誌論文
抄録
Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung that is characterized by the proliferation of fibroblasts and increased deposition of the extracellular matrix. The CCN6/WISP-3 is a member of the CCN family of matricellular proteins, which consists of six members that are involved in many vital biological functions. However, the regulation of lung fibroblasts mediated by CCN6 protein has not been fully elucidated. Here, we demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin β1, leading to the phosphorylation of FAKY397. Furthermore, CCN6 showed a weak, but significant, ability to stimulate the expression of fibronectin. CCN6 was highly expressed in the lung tissues of mice treated with bleomycin. Our results suggest that CCN6 plays a role in the fibrogenesis of the lungs mainly by stimulating the growth of lung fibroblasts and is a potential target for the treatment of pulmonary fibrosis.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
58
3-4
開始ページ
188
終了ページ
196
並び順
188
発行日
2011
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院