ID | 110415 |
タイトルヨミ | シュウジュツキ ノ ケッカン キノウ ホゴ センリャク
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タイトル別表記 | Protective effects of anesthetics and perioperative managements on vascular function
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著者 |
増矢, 幸子
徳島大学大学院医歯薬学研究部地域医療人材育成分野
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キーワード | Vascular function
Anesthetics
KATP channel
Oxidative stress
Intensive insulin therapy
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資料タイプ |
学術雑誌論文
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抄録 | Potassium channels play an essential role in the membrane potential of arterial smooth muscle, and also in regulating contractile tone. Especially, in vascular smooth muscle, the opening of adenosine triphosphate(ATP)-sensitive potassium(KATP)channels leads to membrane hyperpolarization, resulting in muscle relaxation and vasodilation. This activation also plays a role in tissues during pathophysiologic events such as ischemia, hypoxia, and vasodilatory shock. In this review, we will describe the physiological and pathophysiological roles of vascular smooth muscle KATP channels in relation to the effects of anesthetics and perioperative managements. Although accumulated evidence suggests that many anesthetics and perioperative managements(especially, diabetes and hyperglycemia)modify the above function of K+ channels as a metabolic sensor. Use of effective volatile anesthetics and the strict glycemic control may contribute to protect perioperative vascular function.
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掲載誌名 |
四国医学雑誌
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ISSN | 00373699
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cat書誌ID | AN00102041
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出版者 | 徳島医学会
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巻 | 73
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号 | 1-2
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開始ページ | 47
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終了ページ | 58
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並び順 | 47
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発行日 | 2017-04-25
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EDB ID | |
フルテキストファイル | |
言語 |
jpn
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著者版フラグ |
出版社版
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部局 |
医学系
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