ID 83826
タイトルヨミ
ニクガンテキ モンミャク シンシュウ ヨウセイ カンガン セツジョゴ ノ Systemic IFN+Low dose FP ノ ユウヨウセイ : リロンテキ コンキョ ト リンショウテキ コウカ
タイトル別表記
Hepatic resection followed by systemic IFN plus low-dose FP for advanced HCC with macroscopic portal invasion : basic background and clinical outcome
著者
花岡, 潤 徳島大学病院消化器・移植外科
金本, 真美 徳島大学病院消化器・移植外科 KAKEN研究者をさがす
宇都宮, 徹 徳島大学病院消化器・移植外科
キーワード
hepatocellular carcinoma
portal vein tumor thrombus
interferon
chemotherapy
資料タイプ
学術雑誌論文
抄録
Background and Aims : Despite a recent progress of treatment for hepatocellular carcinoma (HCC), the prognosis of advanced HCC with macroscopic vascular invasion remains unsatisfactory. We investigated anti-tumor effect of IFNα using experimental model and show the outcome of our systemic adjuvant therapy consisting of IFNα,5FU and cisplatin(IFP)after hepatectomy on advanced HCC with macroscopic portal invasion. Methods[: Basic study]Anti-tumor effects such as inhibition of invasion, proliferation of pegylated IFN α2b(PegIFNα)was evaluated using MH134mouse HCC cells, in vitro and vivo. [Clinical study]: Thirty patients who had HCC with Vp2or more of macroscopic portal invasion(Vp2; portal vein tumor thrombus in its2nd order branch)were included. Those patients were retrospectively divided into two groups : the systemic IFNα,5FU and cisplatin group (n=14, IFP group); and the no adjuvant therapy group(n=16, control). Clinicopathological variables were compared between the two groups, including patient survival and disease-free survival. Results[: Basic]In vitro, the proliferation was significantly suppressed by Peg-IFNα, and invasion potential was also inhibited. In vivo, tumor growth was significantly suppressed compared to control (0.5vs.5.0cm, p<0.05), and liver metastases was decreased(number :19vs.6, p<0.05). [Clinical]The overall and disease-free survival rate in IFP group was significantly higher than in control group(1y :100% vs38%,3y :65% vs25%, P<0.01,1y :36% vs25%,3y :36% vs19%, P<0.01). Regarding the recurrent patterns,5of9patients in IFP group had controllable tumors in the remnant liver, although12of13patients in control group had distant metastasis or multiple recurrences in the residual liver. Conclusion : Our new adjuvant regimen of systemic IFP may be a promising strategy after radical resection for HCC with macroscopic portal invasion.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
67
3-4
開始ページ
147
終了ページ
154
並び順
147
発行日
2011-08-25
備考
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
病院
医学系