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ID 110995
タイトル別表記
Fbxw7発現低下は大腸癌肝転移切除症例の再発予測因子である
著者
川下, 陽一郎 徳島大学大学院医科学教育部(医学専攻)
Yagi, Toshiyuki Tokushima Prefectural Central Hospital
キーワード
Colorectal liver metastasis
Fbxw7
miR-223
Prognostic factor
資料タイプ
学位論文
抄録
Background/Purpose
Fbxw7 is a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of Fbxw7 is frequently observed in various human cancers. In this study, we examined the role of Fbxw7 expression in colorectal liver metastasis (CRLM) and its mechanism.
Methods
Fifty-six patients with CRLM who undergo curative resection were enrolled. Fbxw7 in tumor tissue was determined by immunohistochemistry. Patients were divided into two groups, the Fbxw7 high and low group. Clinicopathological factors including miR-223 expression were compared between the high (n=32) and low Fbxw7 group (n=24).
Results
Fbxw7 expression in tumor tissues was significantly lower than that in normal tissues. The disease-free survival in the low Fbxw7 group was significantly worse than that in the high Fbxw7 group, and 3years disease-free survival of the low and the high Fbxw7 group were 12.5% and 47.0%, respectively (p=0.023). On multivariate analysis, loss of Fbxw7 was detected as one of the independent risk factor for recurrence of CRLM (Hazard ratio: 2.390, p=0.017). Likewise, Fbxw7 expression inversely correlated to miR-223 expression (p=0.017).
Conclusion
Loss of Fbxw7 in tumor tissues could be a reliable predictor of recurrence after hepatectomy in patients with CRLM, and miR223 might be a possible regulator of Fbxw7.
掲載誌名
Journal of Hepato-Biliary-Pancreatic Sciences
ISSN
18686974
18686982
cat書誌ID
AA12507209
出版者
Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wily
24
10
開始ページ
576
終了ページ
583
発行日
2017-08-28
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yoichiro Kawashitaの学位論文として提出され, 学位審査・授与の対象となっている。
著者の申請により要約(2018-01-11公開)に替えて論文全文を公開(2018-10-17)
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3120号
学位記番号
甲医第1354号
学位授与年月日
2017-11-30
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院