ID | 79154 |
著者 |
西村, 明儒
Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
徳島大学 教育研究者総覧
KAKEN研究者をさがす
|
キーワード | lectin
apoptosis
postmortem diagnosis for schizophrenia
dentate gyrus
spherical deposit
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資料タイプ |
学術雑誌論文
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抄録 | Previously, multi-lectin positive spherical shaped deposits were detected in the
hippocampal formation of degenerative demented and schizophrenic brains and reported they possessed some possibility as a predominant tool of postmortem diagnosis, more detected in schizophrenia cases than age-matched control cases. Multi-fluorescent immunohistochemical and lectin histochemical method and immuno electron microscope method were performed on 51 forensic autopsied brains containing 16 cases of schizophrenia. In multi-fluorescent staining, partial disrupted nucleus with decreased staining properties by mean of SYBR green were detected, and lectin and single strand DNA were co-stained in the portion of partial disrupted nucleus. In immuno electron microscope method, lectin positive structures were also detected in the portion of partial disrupted nucleus. These neurons were suspected in the process of apoptosis by their distinguishable features. Some experimental studies were reported that a kind of therapeutic products of major tranquillizers induced neuron apoptosis in dentate gyrus. As the lectin positive spherical shaped deposits were detected in not only 5 schizophrenia cases without drug treatment but also in 11 schizophrenia cases with drug treatment in this study, they might be detected as the intrinsic pathological change of schizophrenia. The lectin positive spherical shaped deposits detected in the hippocampal formation were suspected as the histopathological marker of the postmortem diagnosis for schizophrenia. Further examination for specifying group of neurons detected them in and initiated apoptosis are necessitated. |
掲載誌名 |
The journal of medical investigation : JMI
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ISSN | 13431420
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cat書誌ID | AA11166929
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巻 | 57
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号 | 3-4
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開始ページ | 183
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終了ページ | 190
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並び順 | 183
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発行日 | 2010-08
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備考 | The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
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EDB ID | |
フルテキストファイル | |
言語 |
eng
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部局 |
医学系
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