ID 110426
タイトルヨミ
ゲンパツセイ アルドステロンショウ ノ シンダン ニ ユウヨウナ リンショウ ショケン ノ ケントウ
タイトル別表記
Clinical parameters for diagnosis of primary aldosteronism
著者
村上, 貴寛 徳島大学病院卒後臨床研修センター
原, 知也 徳島大学病院循環器内科
島袋, 充生 徳島大学病院循環器内科
春藤, 譲治 春藤内科胃腸科
キーワード
Primary aldosteronism
PAC/PRA
low serum potassium
資料タイプ
学術雑誌論文
抄録
Primary aldosteronism(PA)is known as a secondary hypertension. Hypertensive patients are screened by the plasma aldosterone concentration(PAC)/plasma renin activity(PRA)ratio as a case-detection test for PA. However, clinical parameters for screening patients with primary aldosteronism who need adrenalectomy have not been fully elucidated. We report a case of PA who received endoscopic adrenalectomy and evaluated the clinical parameters for screening patients with primary aldosteronism who need adrenalectomy, retrospectively. We evaluated43patients with PAC/PRA>200as a screening test for PA. Thirty-three(77%) patients were diagnoses as PA after confirmation test. In18patients who received adrenal vein sampling, 10 patients were diagnoses as unilateral adrenal adenoma. We compared clinical parameters between PA and non-PA. The level of PAC was lower in patients with PA compared to that in patients with non-PA. There were no significant change in the level of PAC, PAC/PRA, serum potassium, and blood pressure. PAC and PAC/PRA were higher and serum potassium was lower in patients who received adrenalectomy compared to those in patients without adrenalectomy. ROC curve showed that PAC>200 pg/mL and serum potassium <3.5mEq/L were useful parameters to predict diagnosis of PA who need adrenalectomy. In conclusion, PA patients with PAC>200pg/mL and serum potassium <3.5mEq/L should be considered as candidates for adrenorectomy.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
73
1-2
開始ページ
113
終了ページ
116
並び順
113
発行日
2017-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系
病院