ID 113221
タイトル別表記
Combined Predictors for AF
著者
Bando, Sachiko Tokushima University
Matsumoto, Kazuhisa Tokushima University
Nagano, Hiromi Tokushima University
Uematsu, Etsuko Tokushima University
島袋, 充生 Tokushima University|Fukushima Medical University KAKEN研究者をさがす
キーワード
Atrial fibrillation
Left atrial diameter
Premature atrial contraction
資料タイプ
学術雑誌論文
抄録
Background: The ability to identify risk markers for new-onset atrial fibrillation (AF) is critical to the development of preventive strategies, but it remains unknown whether a combination of clinical, electrocardiographic, and echocardiographic parameters predicts the onset of AF. In the present study, we evaluated the predictive value of a combined score that includes these parameters.
Methods and Results: We retrospectively studied 1,040 patients without AF who underwent both echocardiography and 24-h Holter electrocardiography between May 2005 and December 2010. During a median follow-up period of 68.4 months (IQR, 49.9–93.3 months), we investigated the incidence of new-onset AF. Of the 1,040 patients, 103 (9.9%) developed AF. Patients who developed AF were older than patients who did not. Total heart beats, premature atrial contraction (PAC) count, maximum RR interval, and frequency of sinus pause quantified on 24-h electrocardiography were associated with new-onset AF. LA diameter (LAD) on echocardiography was also associated with the development of AF. On multivariate Cox analysis, age ≥58 years, PAC count ≥80 beats/day, maximum RR interval ≥1.64 s, and LAD ≥4.5 cm were independently associated with the development of AF. The incidence rate of new-onset AF significantly increased as the combined score (i.e., the sum of the risk score determined using hazard ratios) increased.
Conclusions: A combined score that includes age, PAC count, maximum RR interval, and LAD could help characterize the risk of new-onset AF.
掲載誌名
Circulation Journal
ISSN
13469843
13474820
cat書誌ID
AA11591968
出版者
The Japanese Circulation Society
82
9
開始ページ
2253
終了ページ
2258
発行日
2018-05-30
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院