ID 113501
著者
フタミ, イスラミ ラフマ Tokushima University
キーワード
Temporomandibular joint
Rheumatoid arthritis
Osteoclast
Fas
S1P1
NF-κB
資料タイプ
学術雑誌論文
抄録
Rheumatoid arthritis (RA) mainly affects various joints of the body, including the temporomandibular joint (TMJ), and it involves an infiltration of autoantibodies and inflammatory leukocytes into articular tissues and the synovium. Initially, the synovial lining tissue becomes engaged with several kinds of infiltrating cells, including osteoclasts, macrophages, lymphocytes, and plasma cells. Eventually, bone degradation occurs. In order to elucidate the best therapy for RA, a comprehensive study of RA pathogenesis needs to be completed. In this article, we discuss a Fas-deficient condition which develops into RA, with an emphasis on the role of sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling which induces the migration of osteoclast precursor cells. We describe that Fas/S1P1 signaling via NF-kB activation in osteoclasts is a key factor in TMJ-RA severity and we discuss a strategy for blocking nuclear translocation of the p50 NF-kB subunit as a potential therapy for attenuating osteoclastogenesis.
掲載誌名
Japanese Dental Science Review
ISSN
18827616
cat書誌ID
AA12334461
出版者
Japanese Association for Dental Science|Elsevier
55
1
開始ページ
12
終了ページ
19
発行日
2018-10-26
権利情報
© 2018 The Authors. Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系