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ID 113015
タイトル別表記
Pathogenesis of Cancer-associated Bone Pain
著者
キーワード
骨痛
V-ATPase
ASIC3
TRPV1
資料タイプ
学術雑誌論文
抄録
Bone pain is a most common and devastating complication associated with bone diseases such as osteoporosis, bone metastasis and rheumatoid arthritis. Thus, control of bone pain is a major goal in the management of these bone diseases. In bone destructive cancer, opioids are first-line therapy but palliative, unsatisfactory and inadequate. Inhibitors of osteoclasts including bisphosphonates and denosumab incompletely reduce bone pain, indicating that not only osteoclast-dependent but also osteoclast-independent mechanisms are operant. In this review, we introduce the recent study including ours, targeting the cancer cell and osteoclast created-acidic extracellular microenvironment for Cancer-associated Bone Pain (CABP).
掲載誌名
Journal of Oral Health and Biosciences
ISSN
21896682
出版者
四国歯学会
31
2
開始ページ
92
終了ページ
96
並び順
92
発行日
2019-02-06
出版社版DOI
出版社版URL
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
歯学系