ID 113792
タイトル別表記
症候性1次性下肢静脈瘤の適切な外科手術は全身性の炎症性物質を軽減する
Systemic Activation of Biomarkers by Varix
著者
荒瀬, 裕己 徳島大学大学院医科学教育部(医学専攻) KAKEN研究者をさがす
Sugasawa, Noriko Tokushima University
Kawatani, Youhei Tokushima University
キーワード
varicose vein
inflammatory biomarkers
IL-6
MCP-1
endovenous laser ablation
資料タイプ
学位論文
抄録
Objective: To evaluate the relationship between systemic inflammatory biomarkers and efficacy of surgical treatment of primary varicose veins of the lower extremities.
Methods: Total 12 patients who underwent endovenous laser ablation or stripping of varicose veins and six healthy subjects were enrolled. Structural and molecular changes of varices were assessed by immunohistochemical staining with anti-monocyte chemotactic protein-1 (MCP-1). MCP-1 and interleukin-6 (IL-6) levels in systemic antecubital blood were measured before and at 12 weeks after treatment.
Results: Immunohistochemical staining revealed prominent manifestation of MCP-1-positive endothelial cells in the walls of varices. Preoperative serum MCP-1 and IL-6 levels in the patients were significantly higher than those in the control (166±12 pg/mL vs 99±10 pg/mL, p=0.003; 5.1±0.95 pg/mL vs 0.0±0.0 pg/mL, p=0.001, respectively). The values were significantly correlated with the severity of chronic venous insufficiency (CVI). Postoperative serum MCP-1 level significantly decreased compared with the preoperative level (152±10 pg/mL vs 166±12 pg/mL, p=0.048). The values after endovenous laser ablation did not significantly decrease compared with those after stripping.
Conclusion: Varicose veins with CVI increase inflammatory biomarker levels in the local tissue and systemic blood. Appropriate treatment of symptomatic varicose veins decreases inflammatory biomarker levels.
掲載誌名
Annals of Vascular Diseases
ISSN
1881641X
18816428
cat書誌ID
AA12366253
出版者
The Editorial Committee of Annals of Vascular Diseases
12
3
開始ページ
367
終了ページ
371
発行日
2019-08-05
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiroki Araseの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
©2019 The Editorial Committee of Annals of Vascular Diseases.
This article is distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the credit of the original work, a link to the license, and indication of any change are properly given, and the original work is not used for commercial purposes. Remixed or transformed contributions must be distributed under the same license as the original.
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3335号
学位記番号
甲医第1429号
学位授与年月日
2019-09-26
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系