アクセス数 : ?
ダウンロード数 : ?
ID 114491
タイトル別表記
Network Changes during tACS Induced Oscillations
著者
Fehér, Kristoffer D. University of Bern
Morishima, Yosuke University of Bern|Japan Science and Technology Agency
キーワード
functional connectivity
effective connectivity
theta oscillations
transcranial magnetic stimulation
transcranial alternating current stimulation
electroencephalography
資料タイプ
学術雑誌論文
抄録
Oscillatory neural activity is considered a basis of signal transmission in brain networks. However, the causal role of neural oscillations in regulating cortico-cortical signal transmission has so far not been directly demonstrated. To date, due to methodological limitations, studies on the online modulatory mechanisms of transcranial alternating current stimulation (tACS)-induced neural oscillations are confined to the primary motor cortex. To address the causal role of oscillatory activity in modulating cortico-cortical signal transmission, we have established a new method using concurrent tACS, transcranial magnetic stimulation (TMS) and electroencephalography (EEG). Through tACS, we introduced 6-Hz (theta) oscillatory activity in the human dorsolateral prefrontal cortex (DLPFC). During tACS, we applied single-pulse TMS over the DLPFC at different phases of tACS and assessed propagation of TMS-induced neural activity with EEG. We show that tACS-induced theta oscillations modulate the propagation of TMS-induced activity in a phase-dependent manner and that phase-dependent modulation is not simply explained by the instantaneous amplitude of tACS. The results demonstrate a phase-dependent modulatory mechanism of tACS at a cortical network level, which is consistent with a causal role of neural oscillations in regulating the efficacy of signal transmission in the brain.
掲載誌名
Frontiers in Human Neuroscience
ISSN
16625161
出版者
Frontiers Media S.A.
11
開始ページ
471
発行日
2017-09-27
権利情報
Copyright © 2017 Fehér, Nakataki and Morishima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). (https://creativecommons.org/licenses/by/4.0/) The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院