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ID 114531
著者
Tsuchida, Kenji Tsuchida Dialysis Access Clinic
Hashimoto, Hirofumi Yoshinogawa Medical Center
Kawahara, Kazuhiko Kamojima Kawashima Clinic
Hayashi, Ikuro Naruto Kawashima Clinic
Fukata, Yoshio Wakimachi Kawashima Clinic
Kashiwagi, Munenori Seijukai Clinic
Yamashita, Akihiro C. Hosei University
Mineshima, Michio Tokyo Women’s Medical University
Tomo, Tadashi Oita University
Masakane, Ikuto Yabuki Hospital
Takemoto, Yoshiaki Osaka City University
Kawanishi, Hideki Tsuchiya General Hospital
Minakuchi, Jun Kawashima Hospital
キーワード
Diabetic nephropathy
Hemodialysis
Intradialytic hypotension
Multicenter prospective study
資料タイプ
学術雑誌論文
抄録
Background: Intradialytic hypotension (IDH) is a common clinical manifestation associated with poor prognosis in hemodialysis (HD) patients. HD patients who suffer from diabetic nephropathy (DN) are increasing and diabetes is a major cause of IDH. Effective interventional treatments for IDH have yet to be fully evaluated. The aim of this multicenter prospective study is to clarify the effect of biocompatible hydrophilic polymer-coated polysulfone (PS) membrane, TORAYLIGHT® NV (NV) dialyzers on IDH.
Methods: This is a prospective stratified-randomized multicenter trial. Forty DN patients undergoing HD and receiving two or more times of treatments for IDH per month were enrolled in this study. They were stratified by the number of treatments for IDH and divided to two groups using NV or conventional PS/polyethersulfone (PES) dialyzers. The number of treatments for IDH and changes in systolic blood pressure (SBP) were monitored for 6 months. Patients’ demographic and clinical characteristics were also collected at enrollment and the last month of the observation period. In order to clarify the patient characteristics that induced preferable effects by using NV dialyzers, responders were defined as the patients whose average SBP falls in 1 month improved from over 30 mmHg to no more than 30 mmHg.
Results: The total number of treatments for IDH decreased significantly in NV group, even though pre-dialysis body weight and ultrafiltration volume were similar. In addition, patients using NV had significantly higher post-dialysis SBP and the lowest SBP during HD at sixth month compared as those in PS/PES group. NV responders had valuables suggesting malnutrition and microinflammation, and better lipid profiles than non-responders. However, the representative markers related to nutritional status, arteriosclerosis, and inflammation were not improved by NV treatment.
Conclusions: NV had preferable effects on IDH in DN HD patients. Our results suggest the usefulness of NV as a possible method to deal with IDH. Further studies are needed to clarify the mechanism of NV effects on hemodynamic status.
掲載誌名
Renal Replacement Therapy
ISSN
20591381
出版者
BioMed Central|Springer Nature
3
開始ページ
58
発行日
2017-12-19
権利情報
© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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言語
eng
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部局
病院