| ID | 118015 |
| 著者 |
Minato, Masanori
Tokushima University
Takahashi, Naoki
University of Fukui
小野, 広幸
Tokushima University
西村, 賢二
Tokushima University
Iwano, Masayuki
University of Fukui
Joh, Kensuke
The Jikei University School of Medicine
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| キーワード | tubulointerstitial nephritis with IgM-positive plasma cells
intracellular crystalline inclusions in the rough endoplasmic reticulum
glucocorticoid dependence
|
| 資料タイプ |
学術雑誌論文
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| 抄録 | Tubulointerstitial nephritis (TIN) with IgM-positive plasma cells (IgMPC-TIN) is an autoimmune kidney disease characterized by IgM/CD138-double-positive plasma cell infiltration in the tubulointerstitium. A 50-year-old man developed IgMPC-TIN and presented with crystalline inclusions in the rough endoplasmic reticulum. Intracellular crystal formation is a rare finding in paraprotein-related kidney diseases, but this case showed no pathogenic monoclonal immunoglobulin. Prednisolone (PSL, 30 mg) improved the TIN, but PSL tapering resulted in the recurrence of TIN. Combination therapy with 15 mg PSL and 150 mg mizoribine ultimately stabilized TIN. This case offers original evidence concerning the pathophysiology and treatment strategy of IgMPC-TIN.
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| 掲載誌名 |
Internal Medicine
|
| ISSN | 13497235
|
| 出版者 | The Japanese Society of Internal Medicine
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| 巻 | 60
|
| 号 | 19
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| 開始ページ | 3129
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| 終了ページ | 3136
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| 発行日 | 2021-10-01
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| 権利情報 | The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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| 言語 |
eng
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| 著者版フラグ |
出版社版
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| 部局 |
医学系
病院
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