| ID | 113373 |
| タイトル別表記 | 過剰な機械的負荷に曝された下顎頭軟骨に対する低出力パルス超音波照射の保護効果
LIPUS effect on osteoarthritic TMJs
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| 著者 |
藤多, 睦
徳島大学大学院口腔科学教育部（口腔科学専攻）
Sato-Shigeta, Minami
Tokushima University
Hassan, Ali H.
King Abdulaziz University
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| キーワード | Temporomandibular joint
Osteoarthritis
Mandibular condyle
Low-intensity pulsed ultrasound
Rats
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| 資料タイプ |
学位論文
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| 抄録 | The aim of this study was to assess the effect of low-intensity pulsed ultrasound (LIPUS) application on rat temporomandibular joints (TMJs) with early-stage of osteoarthritis-like conditions induced by mechanical overloading. Fifteen-week-old male Wistar rats were divided into two experimental groups and a control group (n = 10 each). Both TMJs of all rats in one experimental group were subjected to mechanical overloading for 5 d, and those in the other experimental group were exposed to LIPUS for 20 min/d after overloading. Condyles were assessed using micro-computed tomography, histology and histomorphometry. LIPUS treatment attenuated cartilage degeneration, decreased the number of osteoclastic cells and restored the expression of aggrecan after an initial decrease induced by mechanical overloading. These results indicate that LIPUS may have a protective effect on the early progression of TMJ osteoarthritis.
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| 掲載誌名 |
Ultrasound in Medicine and Biology
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| ISSN | 03015629
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| cat書誌ID | AA00876354
AA11541187
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| 出版者 | Elsevier B.V.|World Federation for Ultrasound in Medicine and Biology
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| 巻 | 45
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| 号 | 4
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| 開始ページ | 944
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| 終了ページ | 953
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| 発行日 | 2019-02-04
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| 備考 | 内容要旨・審査要旨・論文本文の公開
本論文は，著者Mutsumi Fujitaの学位論文として提出され，学位審査・授与の対象となっている。 |
| EDB ID | |
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| フルテキストファイル | |
| 言語 |
eng
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| 著者版フラグ |
博士論文全文を含む
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| 文科省報告番号 | 甲第3283号
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| 学位記番号 | 甲口第448号
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| 学位授与年月日 | 2019-03-22
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| 学位名 |
博士（歯学）
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| 学位授与機関 |
徳島大学
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| 部局 |
歯学系
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