アクセス数 : ?
ダウンロード数 : ?
ID 112363
タイトル別表記
アスペルガー症候群におけるMRSを用いた前部帯状回と小脳の機能評価
MRS Study of ACC in Asperger's Syndrome
著者
郷司, 彩 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
Hisaoka, Sonoka Tokushima University
Abe, Yoko Tokushima University
Miyazaki, Masahito Tokushima University
キーワード
Asperger's Syndrome
Magnetic Resonance Spectroscopy
Anterior Cingulate Cortex
資料タイプ
学位論文
抄録
Purpose
Proton magnetic resonance spectroscopy (1H MRS) is a noninvasive neuroimaging method to quantify biochemical metabolites in vivo and it can serve as a powerful tool to monitor neurobiochemical profiles in the brain. Asperger's syndrome (AS) is a type of autism spectrum disorder, which is characterized by impaired social skills and restrictive, repetitive patterns of interest and activities, while intellectual levels and language skills are relatively preserved. Despite clinical aspects have been well-characterized, neurometabolic profiling in the brain of AS remains to be clear. The present study used proton magnetic resonance spectroscopy (1H MRS) to investigate whether pediatric AS is associated with measurable neurometabolic abnormalities that can contribute new information on the neurobiological underpinnings of the disorder.

Methods
Study participants consisted of 34 children with AS (2-12 years old; mean age 5.2 (±2.0); 28 boys) and 19 typically developed children (2-11 years old; mean age 5.6 (±2.6); 12 boys) who served as the normal control group. The 1H MRS data were obtained from two regions of interest: the anterior cingulate cortex (ACC) and left cerebellum.

Results
In the ACC, levels of N-acetylaspartate (NAA), total creatine (tCr), total choline-containing compounds (tCho) and myo-Inositol (mI) were significantly decreased in children with AS compared to controls. On the other hand, no significant group differences in any of the metabolites were found in the left cerebellum. Neither age nor sex accounted for the metabolic findings in the regions.

Conclusion
The finding of decreased levels of NAA, tCr, tCho, and mI in the ACC but not in left cerebellar voxels in the AS, suggests a lower ACC neuronal density in the present AS cohort compared to controls.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
12
1
開始ページ
e0169288
発行日
2017-01-06
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201704131001.pdf
論文本文:LID201704131002.pdf
本論文は,著者Aya Gojiの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
Copyright: © 2017 Goji et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.( https://creativecommons.org/licenses/by/4.0/ )
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3012号
学位記番号
甲医第1316号
学位授与年月日
2017-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院