ID 112454
タイトル別表記
Current status of prenyl flavonoids
著者
キーワード
Flavonoid
prenyl group
prenylation
biological activity
bioavailability
資料タイプ
学術雑誌論文
抄録
Flavonoids are distributed across the plant kingdom and have attracted substantial attention owing to their potential benefits for human health. Several studies have demonstrated that flavonoids prenylation enhances various biological activities, suggesting an attractive tool for developing functional foods. This review provides an overview of the current knowledge on how prenylation influences the biological activity and bioavailability of flavonoids. The enhancement effect of prenylation on the biological activities of dietary flavonoids in mammals was demonstrated by comparing the effect of 8-prenyl naringenin (8PN) with that of parent naringenin in the prevention of disuse muscle atrophy in mice. This enhancement results from higher muscular accumulation of 8PN than naringenin. As to bioavailability, despite the lower absorption of 8-prenyl quercetin (8PQ) compared with quercetin, higher 8PQ accumulation was found in the liver and kidney. These data imply that prenylation interferes with the elimination of flavonoids from tissues.
掲載誌名
Bioscience, Biotechnology, and Biochemistry
ISSN
09168451
13476947
cat書誌ID
AA10824164
AA12018610
出版者
The Japan Society for Bioscience, Biotechnology, and Agrochemistry|Taylor & Francis
82
2
開始ページ
207
終了ページ
215
発行日
2018-01-08
備考
This is an electronic version of an article published in Bioscience, Biotechnology, and Biochemistry 82, 2, 207-215, 2018.Bioscience, Biotechnology, and Biochemistry is available online at: www.tandfonline.com/10.1080/09168451.2017.1415750.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
生物資源系