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タイトル別表記
網膜静脈閉塞症に対するアフリベルセプト硝子体投与療法後の脈絡膜構造の変化
著者
三田村, 佳典 Tokushima University|Japan Clinical Retina Study Group 徳島大学 教育研究者総覧 KAKEN研究者をさがす
エンカマア, ツェレンナッダミダ 徳島大学大学院医学研究科(医学専攻)
Sano, Hiroki Tokushima University|Japan Clinical Retina Study Group
仁木, 昌徳 Tokushima University|Japan Clinical Retina Study Group 徳島大学 教育研究者総覧
村尾, 史子 Tokushima University|Japan Clinical Retina Study Group 徳島大学 教育研究者総覧
江川, 麻理子 Tokushima University|Japan Clinical Retina Study Group 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Sonoda, Shozo Japan Clinical Retina Study Group|Kagoshima University
Sakamoto, Taiji Japan Clinical Retina Study Group|Kagoshima University
キーワード
choroid
imaging
macula
physiology
binarization
資料タイプ
学位論文
抄録
Aims
To examine the choroidal change accompanying retinal vein occlusion (RVO) in detail, we measured changes in choroidal structure after intravitreal aflibercept (IVA) injections for RVO using binarisation of enhanced depth imaging optical coherence tomographic (EDI-OCT) images and assessed associations with clinical outcome.
Methods
Retrospective, observational case series. Forty treatment-naïve patients (10 central, 18 major branch and 12 macular branch RVO) were examined by EDI-OCT before and 1, 3 and 6 months after IVA injections. EDI-OCT images were binarised using ImageJ. Subfoveal cross-sectional areas of the luminal, stromal and total choroid over a 1500 µm span were measured and the stromal area to total choroidal area (S/C) ratio was calculated.
Results
Compared to normal contralateral eyes, afflicted eyes at baseline exhibited significantly greater stromal area (p<0.001), total choroidal area (p=0.001) and S/C ratio (p<0.001), but no difference in luminal area (p=0.083). The stromal area, S/C ratio and total choroidal area were significantly reduced in afflicted eyes at 1, 3 and 6 months after IVA (all p<0.006). Baseline S/C ratio was significantly correlated with baseline visual acuity (VA), baseline central retinal thickness (CRT) and VA and CRT improvement at 1, 3 and 6 months post-treatment even after adjusting for the axial length, age and sex (all p<0.012).
Conclusion
RVO induces substantial oedema of the choroidal stromal area that is detectable by binarisation of EDI-OCT images. This stromal oedema likely stems from high intraocular vascular endothelial growth factor levels. Changes in choroidal structure may be used to assess severity and prognosis of RVO.
掲載誌名
British Journal of Ophthalmology
ISSN
00071161
14682079
cat書誌ID
AA00574774
出版者
BMJ Publishing Group
105
5
開始ページ
704
終了ページ
710
発行日
2020-07-03
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Tserennadmid Enkhmaaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is an open access article distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is noncommercial. See: http://creativecommons.org/licenses/by-nc/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3668号
学位記番号
甲医第1550号
学位授与年月日
2023-01-26
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院