ID 113012
著者
Maruhashi, Tomoko Tokushima University
Sumitani, Ryohei Tokushima University
Uemura, Munenori Tokushima University
Iwasa, Masami Tokushima University
Hiraga, Takashi National Health Insurance Katsuura Hospital
Kondo, Noriyasu National Health Insurance Katsuura Hospital
Fujita, Hiromi Mahara Institute of Medical Acarology
Mahara, Fumihiko Mahara Hospital
キーワード
Severe fever with thrombocytopenia syndrome
Encephalopathy
Steroid pulse therapy
資料タイプ
学術雑誌論文
抄録
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease caused by the SFTS virus (SFTSV). Clinical symptoms of SFTS often involve encephalopathy and other central neurological symptoms, particularly in seriously ill patients; however, pathogenesis of encephalopathy by SFTSV is largely unknown. Herein, we present case reports of three patients with SFTS, complicated by encephalopathy, admitted to Tokushima University hospital: one patient was a 63-year-old man, while the other two were 83- and 86-year-old women. All of them developed disturbance of consciousness around the 7th day post onset of fever. After methylprednisolone pulse therapy of 500 mg/day, all of them recovered without any neurological sequelae. SFTSV genome was not detected in the cerebrospinal fluid of 2 out of the 3 patients that were available for examination. In these patients, disturbance of consciousness seemed to be an indirect effect of the cytokine storm triggered by SFTSV infection.We propose that short-term glucocorticoid therapy might be beneficial in the treatment of encephalopathy during early phase of SFTSV infection.
掲載誌名
Journal of Infection and Chemotherapy
ISSN
1341321X
cat書誌ID
AA11057978
AA11627318
出版者
Elsevier|The Japanese Society of Chemotherapy|The Japanese Association for Infectious Disease
24
5
開始ページ
389
終了ページ
392
発行日
2018-02-07
権利情報
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
医学系
病院