直近一年間の累計
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ID 116888
タイトル別表記
ベタヒスチンが一側内耳破壊後のラットの前庭代償に与える影響
著者
福田, 潤弥 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
松田, 和徳 Tokushima Prefectural Central Hospital KAKEN研究者をさがす
Kitahara, Tadashi Nara Medical University
Matsuoka, Momoyo University of Tokushima
キーワード
vestibular compensation
betahistine dihydrochloride
medial vestibular nucleus
Fos
histamine H3 receptor
資料タイプ
学位論文
抄録
Background: Vestibular compensation (VC) after unilateral labyrinthectomy (UL) consists of the initial and late processes. These processes can be evaluated based on the decline in the frequency of spontaneous nystagmus (SN) and the number of MK801-induced Fos-positive neurons in the contralateral medial vestibular nucleus (contra-MVe) in rats. Histamine H3 receptors (H3R) are reported to be involved in the development of VC. Objective: We examined the effects of betahistine, an H3R antagonist, on the initial and late processes of VC in UL rats. Methods: Betahistine dihydrochloride was continuously administered to the UL rats at doses of 100 and 200 mg/kg/day using an osmotic minipump. MK801 (1.0 mg/kg) was intraperitoneally administered on days 7, 10, 12, and 14 after UL, while Fos-positive neurons were immunohistochemically stained in the contra-MVe. Results: The SN disappeared after 42 h, and continuous infusion of betahistine did not change the decline in the frequency of SN. The number of MK801-induced Fos-positive neurons in contra-MVe significantly decreased on days 7, 10, and 12 after UL in a dose-dependent manner in the betahistine-treated rats, more so than in the saline-treated rats. Conclusion: These findings suggest that betahistine facilitated the late, but not the initial, process of VC in UL rats.
掲載誌名
Brain Sciences
ISSN
20763425
出版者
MDPI
11
3
開始ページ
360
発行日
2021-03-11
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Junya Fukudaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/ ).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3591号
学位記番号
甲医第1519号
学位授与年月日
2022-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系