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ID 117248
著者
Shono, Hitoshi Tokushima University
Beppu, Kana Tokushima University
Matsushima, Rina Tokushima University
Watanabe, Suzuno Tokushima University
藤本, 知佐 Tokushima University
Ohnishi, Hiroki Tokushima University
Kawai, Misako Ajinomoto
Matsumoto, Hideki Ajinomoto
キーワード
monosodium glutamate
T1R3 genes
head and neck cancer
dysgeusia
資料タイプ
学術雑誌論文
抄録
(Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer.
掲載誌名
Nutrients
ISSN
20726643
出版者
MDPI
13
9
開始ページ
2921
発行日
2021-08-24
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院