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ID 114629
タイトル別表記
Imaging examinations for dementia today
著者
キーワード
Alzheimer’s disease
dementia
amyloid PET
資料タイプ
学術雑誌論文
抄録
In this article, we describe the various diagnostic imaging examinations currently used for evaluating dementia, with a focus on Alzheimer’s disease. There are many diseases that cause dementia, and Alzheimer’s disease is a typical disease, accounting for about 67.6% of dementia cases in patients ≥65 years old. Naturally, it is not possible to diagnose dementia based on an imaging examination alone, but the importance of such examinations as powerful auxiliary tools has been widely recognized. Computed tomography and magnetic resonance imaging can confirm the presence of intracranial diseases, such as brain tumors, chronic subdural hematoma, normal-pressure hydrocephalus and other treatable diseases, as well as cerebral atrophy. Brain perfusion scintigraphy using compounds labeled with a radioisotope, such as 123I, can visualize the blood flow distribution in the brain. After the non-linear transformation to Talairach’s standard brain coordinates, comparing it with a normal database, it is possible to objectively and accurately depict the site of blood flow reduction. Cardiac scintigraphy using 123I-MIBG and dopamine transporter scintigraphy using 123I-ioflupane can also visualize neurotransmitter functions and contribute to the diagnosis of dementia. Amyloid positron emission tomography, which can noninvasively detect the earliest event of Alzheimer’s disease(amyloid β deposition)is also becoming a common imaging examination. With these imaging examinations, the accuracy of diagnosing dementia is improving. Thus, the early diagnosis and differentiation of Alzheimer’s disease are gradually becoming possible thanks to advances in diagnostic imaging. There is currently no fundamental treatment for Alzheimer’s disease, but treatments are available that improve the symptoms or slow progression, so the early diagnosis and treatment/intervention remains important.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
75
5-6
開始ページ
131
終了ページ
136
並び順
131
発行日
2019-12-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
病院