アクセス数 : ?
ダウンロード数 : ?
ID 109987
タイトル別表記
双極性障害におけるグルタミン酸神経伝達異常に関するMRS研究
著者
久保, 弘子 徳島大学大学院医科学教育部(医学専攻) KAKEN研究者をさがす
伊賀, 淳一 Tokushima University|Ehime University KAKEN研究者をさがす
井下, 真利 Tokushima University
Tamaru, Mai Tokushima University
Nakayama-Yamauchi, Chiaki University of Tokushima
Funakoshi, Yasuhiro University of Tokushima
キーワード
Bipolar disorder
glutamate
lithium
sodium valproate
magnetic resonance spectroscopy
Glutamine
資料タイプ
学位論文
抄録
Background: Previous studies of patients with bipolar disorder (BD) using magnetic resonance spectroscopy (MRS) have shown neurophysiological abnormalities related to the glutamate (Glu)-glutamine (Gln) cycle, membrane turnover, and neuronal integrity, although the results were neither consistent nor conclusive. Recently it has been reported the Gln/Glu ratio is the most useful index, quantifying neuronal-glial interactions and the balance of glutamatergic metabolites In this MRS study, we elucidated the abnormalities of metabolites in a larger sample of patients with BD with a high-field MRI system.
Methods: Sixty-two subjects (31 patients with BD and 31 healthy controls [HC]) underwent 3T proton MRS (1H-MRS) of the anterior cingulate cortex (ACC) and left basal ganglia (ltBG) using a stimulated echo acquisition mode (STEAM) sequence.
Results: After verifying the data quality, 20 patients with BD and 23 age- and gender-matched HCs were compared using repeated-measures analysis of covariance (ANCOVA). Compared to the HC group, the BD group showed increased levels of Gln, creatine (Cr), N-acetyl aspartate (NAA), choline (Cho), and an increased ratio of Gln to Glu in the ACC, and increased Gln and Cho in the ltBG. These findings remained after the participants with BD were limited to only euthymic patients. After removing the influence of lithium (Li) and sodium valproate (VPA), we observed activated glutamatergic neurotransmission in the ACC but not in the ltBG. Limitations: The present findings are cross-sectional and metabolites were measured in only two regions.
Conclusions: Our results support a wide range of metabolite changes in patients with BD involved in glutamatergic neurotransmission, membrane turnover, and neuronal integrity. Moreover, the elevation of Gln/Glu ratio suggested that hyperactivity of glutamatergic neurotransmission in the ACC is a disease marker for BD.
掲載誌名
Journal of Affective Disorders
ISSN
01650327
cat書誌ID
AA00256633
AA1153246X
出版者
Elsevier
208
開始ページ
139
終了ページ
144
発行日
2016-10-08
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201701101001.pdf
論文本文 : k3000_fulltext.pdf
著者の申請により要約(2017-01-10公開)に替えて論文全文を公開(2018-11-05)
本論文は, 著者Hiroko Kuboの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3000号
学位記番号
甲医第1305号
学位授与年月日
2016-11-24
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
特別修学支援室
医学系